The pleiotropic benefits of statins

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WebbBeneficial Cardiovascular Pleiotropic Effects of Statins Jean Davignon, MD Abstract—Pleiotropic effects of a drug are actions other than those for which the agent … Webb15 maj 2024 · Statins also impart a modest benefit in concentrations of triglycerides, high-density lipoproteins (HDL) and very low-density lipoproteins (VLDL). 2 Moreover, statins exert pleiotropic effects such as improvement of endothelial function, enhancing the stability of atherosclerotic plaques, decreasing oxidative stress and inflammation, and …

Therapeutics Review: Influenza vaccination reduces Association …

Webb1 maj 2024 · The so-called pleiotropic effects are mediated by the reduction of isoprenoids, such as farnesyl-pyrophosphate and geranylgeranyl-pyrophosphate, necessary for the activation of small GTPases like Rho and Ras proteins (Fig. 1A).Statins diversely inhibit RhoA and Rac1 prenylation, modulating endothelial nitric oxide (NO) synthase … WebbInhibition of protein prenylation for proteins such as RhoA (and subsequent inhibition of Rho-associated protein kinase) may be involved, at least partially, in the improvement of endothelial function, modulation of immune function, and other pleiotropic cardiovascular benefits of statins, as well as in the fact that a number of other drugs that lower LDL … can red crabs gop out of land

Beneficial Cardiovascular Pleiotropic Effects of Statins

Webbwith cardiac history. How might the increasing use of statins, with pleiotropic effects, including antiinflammatory activity, alter the effects of immunization? With universal recommendations for influenza vaccination for persons > 6 months of age, how will herd or community immunity affect population levels of influenza activity? Webb3 okt. 2024 · ObjectiveTo conduct risk assessment and assess the choice of statins ... with no difference between urban and rural areas. 6 Given the burden of CVD and lipid-lowering benefits of statins, ... cholesterol is present in 25% to 30% of urban and 15% to 20% rural subjects. 7 Statins have lipid lowering and number of pleiotropic ... Webbför 6 timmar sedan · select article The pleiotropic effects of high-density lipoproteins and apolipoprotein A-I. https: ... select article The advantages and pitfalls of genetic analysis in the diagnosis and management of lipid disorders. ... Statins and diabetes: What are the connections? Naveed Sattar. Article 101749 View PDF. can red crabs be eaten

The Pleiotropic Effects of Statins in Endocrine Disorders

Isoprenoid Metabolism and the Pleiotropic Effects of Statins

Webb19 apr. 2010 · This article is part I of a 2-part review, and it focuses on the pleiotropic effects of statins at the cellular level. References. Buhaescu I., Izzedine H. Mevalonate pathway: a review of clinical and therapeutical implications . ... Statins: Risk-Benefits and Role in Treating Dyslipidemias. Webb25 mars 2024 · The pleiotropic benefits of statins include the ability to reduce CD47 and amplify the effect of pro-efferocytic therapies in atherosclerosis. Nat. Cardiovasc. Res. 1, … flane red descowareWebbOur study suggests that prior statin use, especially long-term lipophilic statin use, appears to confer preventive benefits against RA. Safety issues regarding the potential risk of … can red creeping thyme grow in colorado

"Webb1 aug. 2002 · Because serum cholesterol level is strongly associated with coronary heart disease (), it has been generally assumed that cholesterol reduction by statins is the predominant, if not the only, mechanism underlying their beneficial effects in cardiovascular diseases.However, subgroup analysis of large clinical trials such as the … " - The pleiotropic benefits of statins

The pleiotropic benefits of statins

Webb6 maj 2016 · These may be predicted as harmful or beneficial effects of the drug. The most wonderful positive pleiotropic effects of statins are anti-inflammatory, anti-proliferative, antithrombotic, improving endothelial dysfunction, and neuroprotective besides many others (Lewington et al. 2007; DuBroff and De Lorgeril 2015 ). Webb7 nov. 2024 · Ultimately, the benefits of statins in an infection setting appear to require attention to the underlying host response and to the timing of the dosage. From this examination of statin efficacy, additional novel host-directed strategies may produce adjunctive therapeutic approaches for the treatment of infection where traditional …

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Webb17 sep. 2015 · “Pleiotropic" effects of statins involve improving endothelial function, decreasing vascular inflammation and oxidative stress, and inhibiting the thrombogenic … Webb5 jan. 2012 · Pleiotropic effects of statins include improvement of endothelial dysfunction, increased nitric oxide bioavailability, antioxidant properties, inhibition of inflammatory …

Webb1 apr. 2002 · These agents appear to reduce bone fractures and may improve insulin sensitivity and reduce the likelihood of persons progressing from impaired glucose … Webb10 mars 2015 · In summary, statins are probably both under- and over-utilized in older adults. For example, it is estimated that only 40-60% of patients over 65 are prescribed a statin after an acute MI; 24 conversely, a recent study found that 30% of patients with a cancer diagnosis were dispensed a statin within 30 days of dying. 25 For primary …

Webb8 okt. 2015 · Thus, statins may modulate the function of cardiovascular cells and key signalling proteins, including small G-proteins, to ultimately exert their pleiotropic effects. Sphingosine-1-phosphate (S1P) is a naturally occurring bioactive lysophospholipid that regulates diverse physiological functions in a variety of different organ systems. Webb20 nov. 2024 · While not increasing the risk of bleeding, these pleiotropic antithrombotic effects may contribute to the overall cardiovascular benefits of statins and certain antihypertensive, antiarrhythmic and antidiabetic drugs. Clinicians and scientists may thus want to consider the ancillary effects in their daily practice and research.

Webb22 apr. 2024 · More than 35 million Americans take statins, most of whom are prescribed Atorvastatin being one of the most popular prescription drugs of its kind. Here are some of the many benefits of taking Atorvastatin medication for patients:. Taking Atorvastatin benefits the body’s cholesterol levels.; Atorvastatin works primarily by reducing low …

Webb1 aug. 2024 · Clinical benefits, such as reduction of recurrent ischemic events, have been documented in a recent prospective study after short-term treatment with statins. 134 Mechanistic explanations of the benefits are derived not only from the actions of statin on atherogenic lipoproteins (VLDL, IDL, and LDL) but equally on inflammation, endothelial … can red copper pan be put in dishwasherWebb15 juni 2007 · Furthermore, at normal doses, statins inhibit cholesterol metabolism by macrophages and may lead to a reduction in macrophage activation and participation in … can red creeping thyme grow in floridaWebb1 okt. 2012 · In recent years, however, a number of additional non-lipid-lowering, or ‘pleiotropic’, effects of statins have been suggested to contribute to their efficacy in … flanel work shirtsWebbEvidence for the pleiotropic effects of statins in heart failure comes largely from retrospective and subgroup analyses of large studies. When statin therapy is compared … flan en thermomix sin hornoWebbPleiotropic effects · Risk factors Abstract Introduction: Autoimmune thyroiditis seems to be associ-ated with increased cardiometabolic risk. Statins, the main-stay of cardiovascular risk reduction and prevention, were found to reduce thyroid antibody titers. The aim of this study was to investigate plasma markers of cardiometabolic risk in flanerie fashionWebbStatins exert pleiotropic effects on the cardiovascular system, in part through an increase in nitric oxide (NO) bioavailability. AMP-activated protein kinase (AMPK) plays a central role in controlling energy and metabolism homeostasis in various organs. We therefore studied whether statins can activate AMPK, and if so, whether the activated ... flaneries horairesWebb1 okt. 2014 · Recent experimental and clinical evidence indicates that some of the cholesterol-independent or "pleiotropic" effects of statins involve improving or restoring endothelial function, enhancing the stability of atherosclerotic plaques, and decreasing oxidative stress and vascular inflammation. 1,280 PDF can red creeping thyme grow in zone 9