Fbw7a
WebApr 1, 2024 · Gain-of-function (GOF), the most malicious oncogenic activity of a cancer-promoting protein, is well illustrated to three hotspot p53 mutations at R248, R175, and … WebTranscription . Fbw7 and Usp28 Regulate Myc Protein Stability in
Fbw7a
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WebShipping Weight : 13 lb 6 oz. Weight of the product as it ships, including packaging. Shipping Dimensions : 23.5” x 9.7” x 11.3”. Dimensions of the product in inches, … WebPreclinical Development Triggering Fbw7-Mediated Proteasomal Degradation of c-Myc by Oridonin Induces Cell Growth Inhibition and Apoptosis Hui-Lin Huang, Heng-You Weng, Lu-Qin Wang, Chun-Hong Yu, Qiao-Juan Huang, Pan-Pan Zhao,
WebFBW7a substrates (e.g., cyclin E, MYC, and JUN) (Figs 1A and EV1B). To examine whether FBW7a interacts with SOX9 and to deter-mine which amino acids may participate in the … WebDownload scientific diagram BLM Increases Fbw7a-Mediated K48-and K63-Linked c-Jun Ubiquitylation (A) Fbw7a-mediated in vitro ubiquitylation of c-Jun occur via mixed …
WebUSP28 Cell proliferation MYC FBW7A 4 DNA damage response TP53BP1, claspin Unknown 3 USP44 Cell cycle regulation CDC20 Unknown 3 CYLD NF-κB signalling TRAF2, TRAF6 NEMO (IKBKG) 4 Cell proliferation BCL3 Unknown 4 UCHL1 Ubiquitin processing Ubiquitin precursors Unknown 1 UCHL5 (UCH37) Proteasomal degradation NFRKB … WebFBW7 Antibody (A301-720A) in WB. Detection of human FBW7 by western blot. Samples: Whole cell lysate (25 µg) from My-La CD4+, HeLa, NCI-H1975, SU-DHL-1, and VLN3G2 …
WebAug 29, 2024 · S2 Fig: Characterization of Fbw7 antibodies.A. Immunoprecipitation (IP) of xFbw7α, β and γ isoforms. xFbw7 isoforms were translated in vitro in the presence of [35 S]-methionine and immunoprecipitated with specific anti-Fbw7 antibodies for phosphorimaging and for immunoblotting analysis with anti-Fbw7 antibodies. (i) and (s) designate the …
WebDownload scientific diagram BLM is ubiquitylated by Fbw7α. (a–c) Degradation of BLM by Fbw7 depends on its N-terminal region, F-box and WD40 domain. U2OS cells were transfected with (a) Flag ... database archivingWebNov 12, 2013 · Wogonin is a plant monoflavonoid which has been reported to inhibit cell growth and/or induce apoptosis in various tumors. The present study examined the apoptosis-inducing activity and underlying mechanism of action of wogonin in A549 cells. The results showed that wogonin was a potent inhibitor of … bit in horse mouthWebDEC1 regulates breast cancer cell proliferation by stabilizing cyclin E protein and delays the progression of cell cycle S phase database as a service dbaas とはWebDec 21, 2024 · Altogether, these results indicate that p53-RS binds to and stabilizes c-Myc in the G1/S phase by preventing its FBW7a-mediated ubiquitination and degradation. Download : Download high-res image (945KB) Download : Download full-size image; Figure 4. p53-RS Interacts with c-Myc at G1/S Phase and Regulates Its Stability databaseassertionmodeWebMay 1, 2009 · B, Fbw7a is a ubiquitin ligase that mono-ubiquitinates SRC-3 on serines 723 and 786 to superactivate SRC-3 and direct it preferentially to certain transcription factors, such as estrogen receptor (ER) and androgen receptor (AR). C, During each subsequent round of transcription, Fbw7a adds one more ubiquitin/round to the two sites. bit in informaticaWebCLIN-E, and PIN1 are degraded specifically by FBW7a [1–3]. FBW7b, however, has remained more enigmatic, partly due to its lower absolute mRNA abundance in several cell lines and tissues, when compared to Fbw7a [2,4]. A further level of complexity of FBW7 function is added by the fact that different substrates are database archiving solutionsWebIn vitro c-Jun ubiquitylation reactions were carried out with non-radiolabeled in vitro transcribed and translated Fbw7a alone or Fbw7a in the presence of a range of … bit in it